Home >Agrochemicals > 4-(Trifluoromethyl)benzenesulfonamide
- Chemical Name: 4-(Trifluoromethyl)benzenesulfonamide
- CAS No.: 830-43-3
Factory Export Top Purity 4-(Trifluoromethyl)benzenesulfonamide 830-43-3 In Stock
- Molecular Formula: C7H6F3NO2S
- Molecular Weight: 225.191
- Appearance/Colour: Colorless to yellow liquid
- Vapor Pressure: 0.000854mmHg at 25°C
- Melting Point: 175-180 °C(lit.)
- Refractive Index: 1.493
- Boiling Point: 304.8 °C at 760 mmHg
- PKA: 9.68±0.10(Predicted)
- Flash Point: 138.1 °C
- PSA： 68.54000
- Density: 1.482 g/cm3
- LogP: 3.13390
4-(Trifluoromethyl)benzenesulfonamide(Cas 830-43-3) Usage
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General Description |
4-(Trifluoromethyl)benzenesulfonamide is a chemical compound with the molecular formula C7H6F3NO2S. It is categorized under the class of benzenesulfonamides, organic compounds containing a sulfonamide group that is S-linked to a benzene ring. The trifluoromethyl group attached to the benzene ring enhances the compound’s chemical stability and reactivity due to the high electronegativity of fluorine atoms, thus influencing its physical and chemical properties. It is primarily known for its usage in the synthesis of other chemical compounds and may be used in the production of pharmaceuticals and various other industrial products. However, it should be handled with care, as it can be harmful if inhaled, ingested, or comes in contact with the skin or eyes. |
InChI:InChI=1/C7H6F3NO2S/c8-7(9,10)5-1-3-6(4-2-5)14(11,12)13/h1-4H,(H2,11,12,13)
830-43-3 Relevant articles
Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides, and Primary Sulfonamides
Lo, Pui Kin Tony,Willis, Michael C.
, p. 15576 - 15581 (2021/10/02)
We report a redox-neutral Ni(II)-catalyz...
Tetrahydropyridines via FeCl3-Catalyzed Carbonyl-Olefin Metathesis
Gaviria, Mario A.,Groso, Emilia J.,Richardson, Alistair D.,Rykaczewski, Katie A.,Schindler, Corinna S.,Vonesh, Hannah L.,Zehnder, Troy E.
supporting information, (2020/04/02)
Herein we describe the application of Le...
Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols
Laudadio, Gabriele,Barmpoutsis, Efstathios,Schotten, Christiane,Struik, Lisa,Govaerts, Sebastian,Browne, Duncan L.,No?l, Timothy
supporting information, (2019/04/16)
Sulfonamides are key motifs in pharmaceu...
Sulfonamide Synthesis through Electrochemical Oxidative Coupling of Amines and Thiols
Laudadio, Gabriele,Barmpoutsis, Efstathios,Schotten, Christiane,Struik, Lisa,Govaerts, Sebastian,Browne, Duncan L.,No?l, Timothy
supporting information, p. 5664 - 5668 (2019/04/17)
Sulfonamides are key motifs in pharmaceu...
830-43-3 Process route
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2-methyl-2-(4-trifluoromethylbenzenesulfonylamino)propionic acid
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830-43-3
4-(trifluoromethyl)benzenesulfonamide
| Conditions | Yield |
|---|---|
|
With
oxygen; copper(II) oxide;
In
dimethyl sulfoxide;
at 100 ℃;
for 8h;
|
89%
|
-
-
2991-42-6
4-trifluorophenylsulfonyl chloride
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-
830-43-3
4-(trifluoromethyl)benzenesulfonamide
| Conditions | Yield |
|---|---|
|
With
ammonia;
|
83%
|
|
With
ammonium hydroxide;
for 1h;
Yield given;
Heating;
|
|
|
With
ammonium hydroxide;
In
acetonitrile;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
|
|
|
With
ammonium hydroxide;
In
dichloromethane;
at -78 ℃;
|
|
|
Multi-step reaction
with
2
steps
1.1: sodium hydrogencarbonate; sodium sulfite; water / 4 h / 80 °C
2.1: iodine / 0.33 h / 20 °C / Green chemistry
2.2: 3 h / 20 °C / Green chemistry
With
water; iodine; sodium hydrogencarbonate; sodium sulfite;
|
|
|
Multi-step reaction
with
2
steps
1: sodium hydroxide
2: copper(II) oxide; oxygen / dimethyl sulfoxide / 8 h / 100 °C
With
oxygen; copper(II) oxide; sodium hydroxide;
In
dimethyl sulfoxide;
|
|
|
With
ammonium hydroxide;
at 100 ℃;
for 1h;
|
|
|
With
ammonium hydroxide;
at 20 ℃;
for 16h;
|
830-43-3 Upstream products
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2991-42-6
4-trifluorophenylsulfonyl chloride
-
455-14-1
4-trifluoromethylphenylamine
-
825-83-2
4-trifluoromethylbenzenethiol
-
108-91-8
cyclohexylamine
830-43-3 Downstream products
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2992-34-9
N-Ethoxymethylen-α,α,α-trifluor-p-toluolsulfonamid
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186800-78-2
N-(4-trifluoromethylbenzenesulfonyl)benzaldimine
-
199589-49-6
3-[1-benzo[1,3]dioxol-5-yl-2-oxo-2-(4-trifluoromethyl-benzenesulfonylamino)-ethyl]-1-methyl-1H -indole-6-carboxylic acid
-
206065-72-7
3-(2,4-dichlorobenzyl)-2-methyl-5-((4-trifluoromethylbenzene)-sulfonylcarbamoyl)indole